Electrically operated sodium channels in the somatic membrane of sympathetic neurons

N. S. Veselovskii, S. A. Fedulova, Roman Shirokov

Research output: Contribution to journalArticlepeer-review

Abstract

Electrically operated sodium channels in the somatic membrane of isolated neurons from the rat superior cervical ganglion were investigated using an intracellular dialysis technique and voltage clamping. It was found that sodium currents can be conveyed along two independent systems of sodium channels in these neurons. A mathematical analysis was made of voltage-dependent tetrodotoxin-sensitive fast sodium currents within the framework of the Hodgkin-Huxley model and their kinetic properties were compared with those described in other subjects. It was also shown that the tetrodotoxin-sensitive sodium channels in the somatic membrane of sympathetic neurons have a high affinity for sodium ions. The kinetic and voltage-dependent characteristics of slow tetrodotoxin-sensitive inward sodium current are described. It is also noted that this component of the sodium current was observed in only a limited number of neurons (not more than 2%).

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalNeurophysiology
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Fingerprint Dive into the research topics of 'Electrically operated sodium channels in the somatic membrane of sympathetic neurons'. Together they form a unique fingerprint.

Cite this