Electroretinogram in withdrawn cocaine-dependent subjects: Relationship to cue-elicited craving

D. A. Smelson, M. Roy, A. Roy, S. Santana

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: We have previously reported that people who are cocaine- dependent have reduced blue cone b-wave electroretinogram (ERG) responses. In this preliminary study, we examined the relationship between blue cone ERG amplitudes and craving response to cocaine cues. Method: A new series of 14 recently withdrawn subjects who were cocaine-dependent completed a cocaine craving questionnaire at baseline, and again following exposure to laboratory cues; an ERG was also performed. Results: Cocaine-dependent subjects with a blunted ERG blue cone response (<0.5 μV) showed significantly greater increases in craving following cue-exposure than subjects without the blunted ERG blue cone response. Conclusions: Subjects with a blunted ERG response may represent a subgroup more vulnerable to cocaine craving and relapse.

Original languageEnglish (US)
Pages (from-to)537-539
Number of pages3
JournalBritish Journal of Psychiatry
Issue numberJUNE
StatePublished - Jun 1998

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health


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