Background: We have previously reported that people who are cocaine- dependent have reduced blue cone b-wave electroretinogram (ERG) responses. In this preliminary study, we examined the relationship between blue cone ERG amplitudes and craving response to cocaine cues. Method: A new series of 14 recently withdrawn subjects who were cocaine-dependent completed a cocaine craving questionnaire at baseline, and again following exposure to laboratory cues; an ERG was also performed. Results: Cocaine-dependent subjects with a blunted ERG blue cone response (<0.5 μV) showed significantly greater increases in craving following cue-exposure than subjects without the blunted ERG blue cone response. Conclusions: Subjects with a blunted ERG response may represent a subgroup more vulnerable to cocaine craving and relapse.
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health