Emergence of ceftazidime-avibactam resistance and restoration of carbapenem susceptibility in Klebsiellapneumoniae carbapenemase- producing K pneumoniae: A case report and review of literature

Ryan K. Shields, M. Hong Nguyen, Ellen G. Press, Liang Chen, Barry N. Kreiswirth, Cornelius J. Clancy

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

We used meropenem to successfully treat a patient with bacteremia due to ceftazidime-avibactam-resistant, meropenemsusceptible Klebsiella pneumoniae that carried mutant blaKPC-3. Meropenem was bactericidal against ceftazidime-avibactamresistant K pneumoniae isolates in vitro. Nevertheless, the role of carbapenems in treating such infections remains uncertain, because meropenem resistance is selected readily during passage experiments.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalOpen Forum Infectious Diseases
Volume4
Issue number3
DOIs
StatePublished - Jul 1 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology

Keywords

  • Carbapenem-resistant Enterobacteriaceae
  • Ceftazidime-avibactam resistance
  • KPC mutations
  • Klebsiella pneumoniae carbapenemase
  • Sequence type 258 Klebsiella pneumoniae

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