Emergence of mobile tigecycline resistance mechanism in Escherichia coli strains from migratory birds in China

Chong Chen, Chao Yue Cui, Yan Zhang, Qian He, Xiao Ting Wu, Gong Li, Xiao Ping Liao, Barry N. Kreiswirth, Ya Hong Liu, Liang Chen, Jian Sun

Research output: Contribution to journalLetter

10 Scopus citations

Abstract

Plasmid-mediated antimicrobial resistance has emerged as one of the principal global issues, posing significant threats to public health. Herein, we reported a mobile tigecycline resistance mechanism Tet(X4) on both plasmid and chromosome in Escherichia coli strains from migratory birds in China. Besides tigecycline, these tet(X4)-positive strains also exhibited elevated MICs to the FDA newly approved tetracycline antibiotics, eravacycline (4 µg/ml) and omadacycline (8 µg/ml). Worrisomely, the tet(X4)-carrying plasmids and chromosome also shared high homology with the plasmids from human. Taken together, Tet(X4) represents another emerging antimicrobial threat and collective efforts from different sectors are needed to control its further spread.

Original languageEnglish (US)
Pages (from-to)1219-1222
Number of pages4
JournalEmerging Microbes and Infections
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Epidemiology
  • Microbiology
  • Immunology
  • Drug Discovery
  • Virology
  • Infectious Diseases

Keywords

  • Tigecycline resistance
  • eravacycline
  • migratory birds
  • omadacycline
  • tet(X4)

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