Emergence of resistance to colistin during the treatment of bloodstream infection caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae

Antibacterial Resistance Leadership Group

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume5
Issue number4
DOIs
StatePublished - Apr 1 2018

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology

Keywords

  • Carbapenemase
  • Colistin resistance
  • Klebsiella pneumoniae

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