Emerging roles for multimodal optical imaging in early cancer detection: A global challenge

Noah Bedard, Mark Pierce, Adel El-Naggar, S. Anandasabapathy, Ann Gillenwater, R. Richards-Kortum

Research output: Contribution to journalComment/debatepeer-review

23 Scopus citations


Medical imaging technologies have become increasingly important in the clinical management of cancer, and now play key roles in cancer screening, diagnosis, staging, and monitoring response to treatment. Standard imaging modalities such as MRI, PET, and CT require significant financial resources and infrastructure, which limits access to these modalities to those patients in high-resource settings. In contrast, optical imaging strategies, with the potential for reduced cost and enhanced portability, are emerging as additional tools to facilitate the early detection and diagnosis of cancer. This article presents a vision for an expanding role for optical imaging in global cancer management, including screening, early detection at the point-of-care, biopsy guidance, and real-time histology. Multi-modal optical imaging - the combination of wide field and high resolution imaging - has the potential to aid in the detection and management of precancer and early cancer for traditionally underserved populations. Several recent widefield and high-resolution optical imaging technologies are described, along with requirements for implementing such devices into lower-resource settings.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalTechnology in Cancer Research and Treatment
Issue number2
StatePublished - Apr 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


  • Clinicaldiagnostics
  • High-resolution imaging
  • Microscopy
  • Widefield imaging


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