Emotional enhancement of memory via amygdala-driven facilitation of rhinal interactions

Rony Paz, Joe Guillaume Pelletier, Elizabeth P. Bauer, Denis Paré

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Emotions generally facilitate memory, an effect mediated by the basolateral amygdala (BLA). To study the underlying mechanisms, we recorded BLA, perirhinal and entorhinal neurons during an appetitive trace-conditioning task. We focused on the rhinal cortices because they constitute the interface between the hippocampus, a mediator of memory consolidation, and the neocortex, the storage site of declarative memories. We found that, after unexpected rewards, BLA activity increased impulse transmission from perirhinal to entorhinal neurons and that this effect decayed as the association between conditioned stimuli and rewards was learned. At this late phase of learning, the BLA effect occurred when the animals were anticipating the reward. By enhancing the processing of sensory cues, the BLA-mediated facilitation of rhinal interactions may explain how the amygdala promotes memory formation in emotional conditions.

Original languageEnglish (US)
Pages (from-to)1321-1329
Number of pages9
JournalNature Neuroscience
Volume9
Issue number10
DOIs
StatePublished - Oct 2006

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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