Endocrine and metabolic regulation of transporters for organic cations

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The disposition of organic cations in the liver and kidneys are under a dynamic regulation by the endocrine and metabolic systems of the body. Researchers have demonstrated the ability of steroids, sex hormones, and physiological states such as pregnancy to alter the expresion and function of transporter proteins that mediate the uptake and efflux of organic cations. This chapter reviews the endocrine and metabolic pathways that influence the pharmacokinetics as well as the toxicity of organic cations.

Original languageEnglish (US)
Title of host publicationOrganic Cation Transporters
Subtitle of host publicationIntegration of Physiology, Pathology, and Pharmacology
PublisherSpringer International Publishing
Pages171-185
Number of pages15
ISBN (Electronic)9783319237930
ISBN (Print)9783319237923
DOIs
StatePublished - Jan 1 2015

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All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Keywords

  • Diabetes
  • Estradiol
  • Gender
  • Glucocorticoid
  • Obesity
  • Testosterone

Cite this

Aleksunes, L. (2015). Endocrine and metabolic regulation of transporters for organic cations. In Organic Cation Transporters: Integration of Physiology, Pathology, and Pharmacology (pp. 171-185). Springer International Publishing. https://doi.org/10.1007/978-3-319-23793-0_6