Endocytic control of growth factor signalling: Multivesicular bodies as signalling organelles

Radek Dobrowolski, Edward M. De Robertis

Research output: Contribution to journalReview article

107 Citations (Scopus)

Abstract

Signal transduction and endocytosis are intertwined processes. The internalization of ligand-activated receptors by endocytosis has classically been thought to attenuate signals by targeting receptors for degradation in lysosomes, but it can also maintain signals in early signalling endosomes. In both cases, localization to multivesicular endosomesen route to lysosomes is thought to terminate signalling. However, during WNT signal transduction, sequestration of the enzyme glycogen synthase kinase 3 (GSK3) inside multivesicular endosomes results in the stabilization of many cytosolic proteins. Thus, the role of endocytosis during signal transduction may be more diverse than anticipated, and multivesicular endosomes may constitute a crucial signalling organelle.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Multivesicular Bodies
Endosomes
Endocytosis
Organelles
Signal Transduction
Intercellular Signaling Peptides and Proteins
Lysosomes
Glycogen Synthase Kinase 3
Ligands
Enzymes
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

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Endocytic control of growth factor signalling : Multivesicular bodies as signalling organelles. / Dobrowolski, Radek; De Robertis, Edward M.

In: Nature Reviews Molecular Cell Biology, Vol. 13, No. 1, 01.01.2012, p. 53-60.

Research output: Contribution to journalReview article

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