Endothelial monocyte activating polypeptide ii induces endothelial cell apoptosis and may inhibit tumor angiogenesis

Adam C. Berger, H. Richard Alexander, Guangquing Tang, Peter S. Wu, Stephen M. Hewitt, Ewa Turner, Erwin Kruger, William D. Figg, Andrew Grove, Elise Kohn, David Stern, Steven Libutti

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Endothelial monocyte activating polypeptide II (EMAP-II) is a tumor-derived cytokine with potent effects on endothelial cells in vitro and in vivo including upregulation of tissue factor and the sensitization of human melanoma to systemic TNF treatment via its effects on the tumor vasculature. We investigated the effects of EMAP-II on tumor growth, angiogenesis, vasculogenesis, and apoptosis. EMAP-II inhibited endothelial cell proliferation, vasculogenesis, and neovessel formation. In vivo growth of human melanoma lines expressing high amounts of EMAP-II demonstrated slower growth, smaller tumors, and increased amounts of tumor necrosis than those expressing lower amounts of EMAP-II. EMAP-II induced endothelial-cell-specific apoptosis via a pathway that includes upregulation of the Fas-associated death domain and downregulation of Bcl-2. EMAP-II appears to have important effects on angiogenesis and may play a role in regulating tumor vascular growth.

Original languageEnglish (US)
Pages (from-to)70-80
Number of pages11
JournalMicrovascular Research
Volume60
Issue number1
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Endothelial cells
Tumors
Monocytes
Endothelial Cells
Apoptosis
Peptides
Neoplasms
Growth
Melanoma
Up-Regulation
Cell proliferation
Thromboplastin
small inducible cytokine subfamily E, member 1
Blood Vessels
Necrosis
Down-Regulation
Cell Proliferation
Cytokines

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

Berger, Adam C. ; Alexander, H. Richard ; Tang, Guangquing ; Wu, Peter S. ; Hewitt, Stephen M. ; Turner, Ewa ; Kruger, Erwin ; Figg, William D. ; Grove, Andrew ; Kohn, Elise ; Stern, David ; Libutti, Steven. / Endothelial monocyte activating polypeptide ii induces endothelial cell apoptosis and may inhibit tumor angiogenesis. In: Microvascular Research. 2000 ; Vol. 60, No. 1. pp. 70-80.
@article{a68418304fd446a099855d9c6fc89931,
title = "Endothelial monocyte activating polypeptide ii induces endothelial cell apoptosis and may inhibit tumor angiogenesis",
abstract = "Endothelial monocyte activating polypeptide II (EMAP-II) is a tumor-derived cytokine with potent effects on endothelial cells in vitro and in vivo including upregulation of tissue factor and the sensitization of human melanoma to systemic TNF treatment via its effects on the tumor vasculature. We investigated the effects of EMAP-II on tumor growth, angiogenesis, vasculogenesis, and apoptosis. EMAP-II inhibited endothelial cell proliferation, vasculogenesis, and neovessel formation. In vivo growth of human melanoma lines expressing high amounts of EMAP-II demonstrated slower growth, smaller tumors, and increased amounts of tumor necrosis than those expressing lower amounts of EMAP-II. EMAP-II induced endothelial-cell-specific apoptosis via a pathway that includes upregulation of the Fas-associated death domain and downregulation of Bcl-2. EMAP-II appears to have important effects on angiogenesis and may play a role in regulating tumor vascular growth.",
author = "Berger, {Adam C.} and Alexander, {H. Richard} and Guangquing Tang and Wu, {Peter S.} and Hewitt, {Stephen M.} and Ewa Turner and Erwin Kruger and Figg, {William D.} and Andrew Grove and Elise Kohn and David Stern and Steven Libutti",
year = "2000",
month = "1",
day = "1",
doi = "10.1006/mvre.2000.2249",
language = "English (US)",
volume = "60",
pages = "70--80",
journal = "Microvascular Research",
issn = "0026-2862",
publisher = "Academic Press Inc.",
number = "1",

}

Berger, AC, Alexander, HR, Tang, G, Wu, PS, Hewitt, SM, Turner, E, Kruger, E, Figg, WD, Grove, A, Kohn, E, Stern, D & Libutti, S 2000, 'Endothelial monocyte activating polypeptide ii induces endothelial cell apoptosis and may inhibit tumor angiogenesis', Microvascular Research, vol. 60, no. 1, pp. 70-80. https://doi.org/10.1006/mvre.2000.2249

Endothelial monocyte activating polypeptide ii induces endothelial cell apoptosis and may inhibit tumor angiogenesis. / Berger, Adam C.; Alexander, H. Richard; Tang, Guangquing; Wu, Peter S.; Hewitt, Stephen M.; Turner, Ewa; Kruger, Erwin; Figg, William D.; Grove, Andrew; Kohn, Elise; Stern, David; Libutti, Steven.

In: Microvascular Research, Vol. 60, No. 1, 01.01.2000, p. 70-80.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Endothelial monocyte activating polypeptide ii induces endothelial cell apoptosis and may inhibit tumor angiogenesis

AU - Berger, Adam C.

AU - Alexander, H. Richard

AU - Tang, Guangquing

AU - Wu, Peter S.

AU - Hewitt, Stephen M.

AU - Turner, Ewa

AU - Kruger, Erwin

AU - Figg, William D.

AU - Grove, Andrew

AU - Kohn, Elise

AU - Stern, David

AU - Libutti, Steven

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Endothelial monocyte activating polypeptide II (EMAP-II) is a tumor-derived cytokine with potent effects on endothelial cells in vitro and in vivo including upregulation of tissue factor and the sensitization of human melanoma to systemic TNF treatment via its effects on the tumor vasculature. We investigated the effects of EMAP-II on tumor growth, angiogenesis, vasculogenesis, and apoptosis. EMAP-II inhibited endothelial cell proliferation, vasculogenesis, and neovessel formation. In vivo growth of human melanoma lines expressing high amounts of EMAP-II demonstrated slower growth, smaller tumors, and increased amounts of tumor necrosis than those expressing lower amounts of EMAP-II. EMAP-II induced endothelial-cell-specific apoptosis via a pathway that includes upregulation of the Fas-associated death domain and downregulation of Bcl-2. EMAP-II appears to have important effects on angiogenesis and may play a role in regulating tumor vascular growth.

AB - Endothelial monocyte activating polypeptide II (EMAP-II) is a tumor-derived cytokine with potent effects on endothelial cells in vitro and in vivo including upregulation of tissue factor and the sensitization of human melanoma to systemic TNF treatment via its effects on the tumor vasculature. We investigated the effects of EMAP-II on tumor growth, angiogenesis, vasculogenesis, and apoptosis. EMAP-II inhibited endothelial cell proliferation, vasculogenesis, and neovessel formation. In vivo growth of human melanoma lines expressing high amounts of EMAP-II demonstrated slower growth, smaller tumors, and increased amounts of tumor necrosis than those expressing lower amounts of EMAP-II. EMAP-II induced endothelial-cell-specific apoptosis via a pathway that includes upregulation of the Fas-associated death domain and downregulation of Bcl-2. EMAP-II appears to have important effects on angiogenesis and may play a role in regulating tumor vascular growth.

UR - http://www.scopus.com/inward/record.url?scp=0033947124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033947124&partnerID=8YFLogxK

U2 - 10.1006/mvre.2000.2249

DO - 10.1006/mvre.2000.2249

M3 - Article

C2 - 10873516

AN - SCOPUS:0033947124

VL - 60

SP - 70

EP - 80

JO - Microvascular Research

JF - Microvascular Research

SN - 0026-2862

IS - 1

ER -