Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation

Zhiping Pang, Guang Y. Ling, Mahadevan Gajendiran, Zao C. Xu

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The synaptic transmission and intrinsic membrane properties of spiny neurons in rat neostriatum were studied after unilateral dopamine depletion using in vivo intracellular recording and staining techniques. Two to four weeks after dopamine denervation, the spontaneous firing rate of spiny neurons increased and the spontaneous membrane potential fluctuation stayed at a more depolarized state for longer periods of time. The amplitude of cortically evoked initial excitatory postsynaptic potentials increased and a late excitatory postsynaptic potential that was occasionally found in control neurons was elicited from 23% of spiny neurons after dopamine denervation. No significant changes in intrinsic membrane properties of spiny neurons were observed after dopamine denervation. These results suggest that dopamine inhibits excitatory synaptic transmission of spiny neurons in naïve animals.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalNeuroscience Letters
Volume308
Issue number3
DOIs
StatePublished - Aug 10 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Dopamine
  • Excitatory synaptic transmission
  • Intracellular recordings
  • Spiny neuron
  • Striatum

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