Enhanced fitness and renal function in Type 2 diabetes

E. S. Nylen, S. M. Gandhi, R. Kheirbek, P. Kokkinos

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Aims: To investigate the renal effects of fitness in people with diabetes with mild renal dysfunction. Methods: The effect of a 12-week exercise programme on estimated GFR in 128 people with diabetes was evaluated. Results: All cardiometabolic variables improved after 12weeks of supervised exercise. Although there was a modest 3.9% increase in estimated GFR from baseline in the 128 people who completed the study, those with baseline chronic kidney disease stages 2 and 3 were found to have significant (6 and 12%, respectively; p<0.01) improvements in post-exercise estimated GFR. Moreover, 42% of the people with chronic kidney disease stage 3 improved to chronic kidney disease stage 2 after the intervention. Conclusion: Short-term exercise improves renal function in those with more moderate baseline chronic kidney disease. Thus, renal function appears to be responsive to enhanced physical fitness. Being a strong and modifiable risk factor, enhanced fitness should be considered a non-pharmacological adjunct in the management of diabetic kidney disease.

Original languageEnglish (US)
Pages (from-to)1342-1345
Number of pages4
JournalDiabetic Medicine
Issue number10
StatePublished - Oct 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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