Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

Jerimy C. Polf, Lawrence F. Bronk, Wouter H.P. Driessen, Wadih Arap, Renata Pasqualini, Michael Gillin

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

The development and use of sensitizing agents to improve the effectiveness of radiotherapy have long been sought to improve our ability to treat cancer. In this letter, we have studied the relative biological effectiveness of proton beam radiotherapy on prostate tumor cells with and without internalized gold nanoparticles. The effectiveness of proton radiotherapy for the killing of prostate tumor cells was increased by approximately 15%-20% for those cells containing internalized gold nanoparticles.

Original languageEnglish (US)
Article number193702
JournalApplied Physics Letters
Volume98
Issue number19
DOIs
StatePublished - May 9 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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