Enhancement of idiotype-anti-idiotype T cell interactions by monoclonal OKT11A antibody

Christine Rohowsky-Kochan; Patrick Kung; Donald W. King; Nicole Suciu-Foca

doi:10.1016/0198-8859(84)90032-6

Enhancement of idiotype-anti-idiotype T cell interactions by monoclonal OKT11A antibody

Christine Rohowsky-Kochan, Patrick Kung, Donald W. King, Nicole Suciu-Foca

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We have demonstrated that OKT11A, a mouse monoclonal antibody recognizing the E receptor on human T lymphocytes, strongly enhances the autologous mixed lymphocyte culture (AMLC) response induced by T lymphoblasts, while inhibiting the AMLC response induced by B lymphoblasts as well as the T cell response to alloantigens and soluble antigens. This antibody seems to enhance the idiotype-anti-idiotype interaction between resting and activated T lymphocytes.

Original language	English (US)
Pages (from-to)	103-110
Number of pages	8
Journal	Human Immunology
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0198-8859(84)90032-6
State	Published - Feb 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/0198-8859(84)90032-6

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@article{b298efa998e14bbcaf29781fad2d18d2,

title = "Enhancement of idiotype-anti-idiotype T cell interactions by monoclonal OKT11A antibody",

abstract = "We have demonstrated that OKT11A, a mouse monoclonal antibody recognizing the E receptor on human T lymphocytes, strongly enhances the autologous mixed lymphocyte culture (AMLC) response induced by T lymphoblasts, while inhibiting the AMLC response induced by B lymphoblasts as well as the T cell response to alloantigens and soluble antigens. This antibody seems to enhance the idiotype-anti-idiotype interaction between resting and activated T lymphocytes.",

author = "Christine Rohowsky-Kochan and Patrick Kung and King, {Donald W.} and Nicole Suciu-Foca",

note = "Funding Information: The authors gratefully acknowledge the excellent technical assistance of Gisela Perez and Amy Lewison. We thank Mildred Rodriguez for her secretarial assistance. This work was supported by grants 1-POL-AGO-2307 and NO1-AI-82552 from the NIH. OKT antibodies were a generous gift from Ortho Diagnostics Laboratories, Raritan, NJ.",

year = "1984",

month = feb,

doi = "10.1016/0198-8859(84)90032-6",

language = "English (US)",

volume = "9",

pages = "103--110",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "2",

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TY - JOUR

T1 - Enhancement of idiotype-anti-idiotype T cell interactions by monoclonal OKT11A antibody

AU - Rohowsky-Kochan, Christine

AU - Kung, Patrick

AU - King, Donald W.

AU - Suciu-Foca, Nicole

N1 - Funding Information: The authors gratefully acknowledge the excellent technical assistance of Gisela Perez and Amy Lewison. We thank Mildred Rodriguez for her secretarial assistance. This work was supported by grants 1-POL-AGO-2307 and NO1-AI-82552 from the NIH. OKT antibodies were a generous gift from Ortho Diagnostics Laboratories, Raritan, NJ.

PY - 1984/2

Y1 - 1984/2

N2 - We have demonstrated that OKT11A, a mouse monoclonal antibody recognizing the E receptor on human T lymphocytes, strongly enhances the autologous mixed lymphocyte culture (AMLC) response induced by T lymphoblasts, while inhibiting the AMLC response induced by B lymphoblasts as well as the T cell response to alloantigens and soluble antigens. This antibody seems to enhance the idiotype-anti-idiotype interaction between resting and activated T lymphocytes.

AB - We have demonstrated that OKT11A, a mouse monoclonal antibody recognizing the E receptor on human T lymphocytes, strongly enhances the autologous mixed lymphocyte culture (AMLC) response induced by T lymphoblasts, while inhibiting the AMLC response induced by B lymphoblasts as well as the T cell response to alloantigens and soluble antigens. This antibody seems to enhance the idiotype-anti-idiotype interaction between resting and activated T lymphocytes.

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DO - 10.1016/0198-8859(84)90032-6

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AN - SCOPUS:0021340511

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JO - Human Immunology

JF - Human Immunology

IS - 2

ER -

Enhancement of idiotype-anti-idiotype T cell interactions by monoclonal OKT11A antibody

Abstract

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