Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster

Keetae Kim, Yuh Ru Lin, Yongkyu Park

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Ambient temperature affects the lifespan of cold-blooded organisms such as Drosophila melanogaster. To better understand what influences the lifespan of an adult fruit fly, we tested whether developmental temperature could affect stress responses used as surrogate markers for the aging process. When 2-day-old adult flies developed at two representative temperatures (18 °C and 25 °C) were challenged with three stresses (starvation, oxidation, and heat), both male and female flies developed at 18 °C exhibited stronger resistance to all three stresses compared to those developed at 25 °C. Nutrient composition analyses showed that fat, protein, and glycogen levels increased when male flies were developed at 18 °C. These differences in stress resistance by developmental temperature were sustained even between 30-day-old male flies of two groups aged at the same temperature. We also showed that development at a lower temperature represented by 18 °C significantly downregulates anti-microbial peptide genes, AttA and DptB, of Imd pathway.

Original languageEnglish (US)
Pages (from-to)984-987
Number of pages4
JournalExperimental Gerontology
Volume45
Issue number12
DOIs
StatePublished - Dec 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Keywords

  • Developmental temperature
  • Drosophila
  • Imd pathway
  • Nutritional content
  • Stress resistance

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