Enhancement of transdermal drug delivery

Chemical and physical approaches

Charles S. Asbill, Ayman F. El-Kattan, Bozena Michniak-Kohn

Research output: Contribution to journalReview article

74 Citations (Scopus)

Abstract

Transdermal drug delivery has been intensively studied over the last two decades because of the many advantages offered by this route of administration. However, the number of drugs used in transdermal drug delivery systems has been somewhat limited, in part resulting from the formidable barrier to drug permeation presented by the upper layer of the skin, the stratum corneum. In order to overcome this, different strategies have been implemented to render the skin more permeable to drugs. These strategies include both chemical and physical approaches. In this review, we outline the enhancing activities and mechanisms of action of some of the more extensively studied chemical penetration enhancers (oxazolidinones, propylene glycol, and epidermal enzymes). In addition, we discuss novel physical strategies, such as the use of microneedles or electroporation.

Original languageEnglish (US)
Pages (from-to)621-658
Number of pages38
JournalCritical Reviews in Therapeutic Drug Carrier Systems
Volume17
Issue number6
StatePublished - Dec 1 2000

Fingerprint

Pharmaceutical Preparations
Oxazolidinones
Propylene Glycol
Skin
Electroporation
Drug Delivery Systems
Cornea
Enzymes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

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Enhancement of transdermal drug delivery : Chemical and physical approaches. / Asbill, Charles S.; El-Kattan, Ayman F.; Michniak-Kohn, Bozena.

In: Critical Reviews in Therapeutic Drug Carrier Systems, Vol. 17, No. 6, 01.12.2000, p. 621-658.

Research output: Contribution to journalReview article

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