Entamoeba histolytica: Computational identification of putative microRNA candidates

Subhajyoti De, Dibyarupa Pal, Sudip K. Ghosh

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

MicroRNAs are an abundant class of ∼20-24-nucleotide noncoding RNAs that control the expression of several genes at the post-transcriptional level, regulating several important biochemical pathways. MicroRNAs have been identified in many vertebrates including humans, and also in flies, nematodes, plants, and viruses. In the present work we have identified seventeen putative candidate microRNAs in the pathogenic parasite Entamoeba histolytica using a bioinformatic approach. Putative microRNA identification in E. histolytica may act as a starting reference for cloning and characterization of miRNAs in Entamoeba genome.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalExperimental Parasitology
Volume113
Issue number4
DOIs
StatePublished - Aug 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology
  • Infectious Diseases

Keywords

  • Eh
  • Entamoeba histolytica
  • Gene regulation
  • MicroRNA
  • Post-transcriptional modification
  • RNA-duplex
  • mRNA
  • messenger ribonucleic acid
  • miRNA
  • microRNA
  • short interfering ribonucleic acid
  • siRNA

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