Enterocin P Selectively Dissipates the Membrane Potential of Enterococcus faecium T136

C. Herranz, Y. Chen, H. J. Chung, L. M. Cintas, P. E. Hernández, T. J. Montville, M. L. Chikindas

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56 Scopus citations


Enterocin P is a pediocin-like, broad-spectrum bacteriocin which displays a strong inhibitory activity against Listeria monocytogenes. The bacteriocin was purified from the culture supernatant of Enterococcus faecium P13, and its molecular mechanism of action against the sensitive strain E. faecium T136 was evaluated. Although enterocin P caused significant reduction of the membrane potential (Δψ) and the intracellular ATP pool of the indicator organism, the pH gradient (ΔpH) component of the proton motive force (Δp) was not dissipated. By contrast, enterocin P caused carboxyfluorescein efflux from E. faecium T136-derived liposomes.

Original languageEnglish (US)
Pages (from-to)1689-1692
Number of pages4
JournalApplied and environmental microbiology
Issue number4
StatePublished - Apr 2001

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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