Enterocyte fatty acid-binding proteins (FABPs): Different functions of liver and intestinal FABPs in the intestine

Angela M. Gajda, Judith Storch

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Fatty acid-binding proteins (FABP) are highly abundant cytosolic proteins that are expressed in most mammalian tissues. In the intestinal enterocyte, both liver- (LFABP; FABP1) and intestinal FABPs (IFABP; FABP2) are expressed. These proteins display high-affinity binding for long-chain fatty acids (FA) and other hydrophobic ligands; thus, they are believed to be involved with uptake and trafficking of lipids in the intestine. In vitro studies have identified differences in ligand-binding stoichiometry and specificity, and in mechanisms of FA transfer to membranes, and it has been hypothesized that LFABP and IFABP have different functions in the enterocyte. Studies directly comparing LFABP- and IFABP-null mice have revealed markedly different phenotypes, indicating that these proteins indeed have different functions in intestinal lipid metabolism and whole body energy homeostasis. In this review, we discuss the evolving knowledge of the functions of LFABP and IFABP in the intestinal enterocyte.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume93
DOIs
StatePublished - Feb 1 2015

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

Keywords

  • Fatty acid
  • Fatty acid-binding protein
  • IFABP
  • Intestine
  • LFABP
  • Lipid

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