Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor

Efstathios S. Giotis, George Carnell, Erik F. Young, Saleena Ghanny, Patricia Soteropoulos, Lin Fa Wang, Wendy S. Barclay, Michael A. Skinner, Nigel Temperton

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.

Original languageEnglish (US)
Pages (from-to)2035-2038
Number of pages4
JournalNature Microbiology
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2019

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Genetics
  • Microbiology (medical)
  • Cell Biology

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