Epigenetic diversity in hematopoietic neoplasms

Rita Shaknovich, Subhajyoti De, Franziska Michor

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Tumor cell populations display a remarkable extent of variability in non-genetic characteristics such as DNA methylation, histone modification patterns, and differentiation levels of individual cells. It remains to be elucidated whether non-genetic heterogeneity is simply a byproduct of tumor evolution or instead a manifestation of a higher-order tissue organization that is maintained within the neoplasm to establish a differentiation hierarchy, a favorable microenvironment, or a buffer against changing selection pressures during tumorigenesis. Here, we review recent findings on epigenetic diversity, particularly heterogeneity in DNA methylation patterns in hematologic malignancies. We also address the implications of epigenetic heterogeneity for the clonal evolution of tumors and discuss its effects on gene expression and other genome functions in cancer.

Original languageEnglish (US)
Pages (from-to)477-484
Number of pages8
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Issue number2
StatePublished - Dec 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research


  • Cancer
  • Epigenetics
  • Heterogeneity
  • Lymphoma


Dive into the research topics of 'Epigenetic diversity in hematopoietic neoplasms'. Together they form a unique fingerprint.

Cite this