Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement

Shusaku Uchida, Gleb P. Shumyatsky

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Recent evidence demonstrates that epigenetic regulation of gene transcription is critically involved in learning and memory. Here, we discuss the role of histone acetylation and DNA methylation, which are two best understood epigenetic processes in memory processes. More specifically, we focus on learning-strength-dependent changes in chromatin on the fibroblast growth factor 1 (Fgf1) gene and on the molecular events that modulate regulation of Fgf1 transcription, required for memory enhancement, with the specific focus on CREB-regulated transcription coactivator 1 (CRTC1).

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalBrain Research Bulletin
StatePublished - Jul 2018

All Science Journal Classification (ASJC) codes

  • General Neuroscience


  • CRTC1
  • Epigenetics
  • FGF1
  • Gene transcription
  • Memory enhancement
  • Memory formation


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