Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer

Renyi Wu, Lujing Wang, Ran Yin, Rasika Hudlikar, Shanyi Li, Hsiao Chen D. Kuo, Rebecca Peter, Davit Sargsyan, Yue Guo, Xia Liu, Ah Ng T. Kong

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Colorectal cancer (CRC) is associated with significant morbidity and mortality in the US and worldwide. CRC is the second most common cancer-related death in both men and women globally. Chronic inflammation has been identified as one of the major risk factors of CRC. It may drive genetic and epigenetic/epigenomic alterations, such as DNA methylation, histone modification, and non-coding RNA regulation. Current prevention modalities for CRC are limited and some treatment regimens such as use the nonsteroidal anti-inflammatory drug aspirin may have severe side effects, namely gastrointestinal ulceration and bleeding. Therefore, there is an urgent need of developing alternative strategies. Recently, increasing evidence suggests that several dietary cancer chemopreventive phytochemicals possess anti-inflammation and antioxidative stress activities, and may prevent cancers including CRC. Curcumin (CUR) is the yellow pigment that is found in the rhizomes of turmeric (Curcuma longa). Many studies have demonstrated that CUR exhibit strong anticancer, antioxidative stress, and anti-inflammatory activities by regulating signaling pathways, such as nuclear factor erythroid-2-related factor 2, nuclear factor-κB, and epigenetics/epigenomics pathways of histones modifications, and DNA methylation. In this review, we will discuss the latest evidence in epigenetics/epigenomics alterations by CUR in CRC and their potential contribution in the prevention of CRC.

Original languageEnglish (US)
Pages (from-to)227-236
Number of pages10
JournalMolecular Carcinogenesis
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2020

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cancer Research

Keywords

  • colon cancer
  • curcumin
  • epigenetics
  • inflammation

Cite this

Wu, R., Wang, L., Yin, R., Hudlikar, R., Li, S., Kuo, H. C. D., Peter, R., Sargsyan, D., Guo, Y., Liu, X., & Kong, A. N. T. (2020). Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer. Molecular Carcinogenesis, 59(2), 227-236. https://doi.org/10.1002/mc.23146