Esthesioneuroblastoma: Correlating FDG uptake on PET/T with tumor histologic grade

Sanaz Harirchian, Arjuna B. Kuperan, Nasrin Ghesani, Neena M. Mirani, Erik G. Cohen, Soly Baredes

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Esthesioneuroblastoma (ENB) is a rare neoplasm arising from the olfactory epithelium of the upper nasal cavity. It exhibits varied clinical behavior with the potential for locoregional recurrence and metastasis. The utility of PET/CT in the evaluation, staging, and follow-up of patients with ENB has not been well characterized, nor has the relationship between PET/CT findings and histologic grade. This study aims to evaluate the potential clinical utility of PET/CT in predicting the tumor's histologic grade. Study design: Retrospective chart review Methods: Seven patients treated for ENB who also had a PET/CT scan were included in the study. All patients had PET/CT scans 1-6 weeks before surgery, and lesions were assigned a peak SUV (standardized uptake value) that was standardized to the liver uptake. Pathology specimens were categorized into grades I-IV according to Hyams histologic grading criteria. The ratio of the lesion to liver uptake was then plotted against the pathological grade of the surgical specimen. Results: Six out of seven patients had direct correlation between the degree of lesion uptake on PET/CT and Hyams histologic grade. Conclusions: This study correlates histologic grade of ENB with FDG avidity on PET/CT. Recent data in the literature notes that the Hyams staging system may be an important factor in determining prognosis for tumor recurrence and survival. Although a small series, our study suggests that PET/CT may be utilized to predict the tumor's histologic grade. Lesion uptake on PET/CT may be utilized as a predictor of outcome and the need for post-surgical adjunctive treatment.

Original languageEnglish (US)
JournalLaryngoscope
Volume121
Issue numberSUPPL. 4
DOIs
StatePublished - Jul 11 2011

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Olfactory Esthesioneuroblastoma
Neoplasms
Recurrence
Olfactory Mucosa
Nasal Cavity
Liver
Retrospective Studies
Pathology
Neoplasm Metastasis
Survival

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Harirchian, S., Kuperan, A. B., Ghesani, N., Mirani, N. M., Cohen, E. G., & Baredes, S. (2011). Esthesioneuroblastoma: Correlating FDG uptake on PET/T with tumor histologic grade. Laryngoscope, 121(SUPPL. 4). https://doi.org/10.1002/lary.21997
Harirchian, Sanaz ; Kuperan, Arjuna B. ; Ghesani, Nasrin ; Mirani, Neena M. ; Cohen, Erik G. ; Baredes, Soly. / Esthesioneuroblastoma : Correlating FDG uptake on PET/T with tumor histologic grade. In: Laryngoscope. 2011 ; Vol. 121, No. SUPPL. 4.
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Harirchian, S, Kuperan, AB, Ghesani, N, Mirani, NM, Cohen, EG & Baredes, S 2011, 'Esthesioneuroblastoma: Correlating FDG uptake on PET/T with tumor histologic grade', Laryngoscope, vol. 121, no. SUPPL. 4. https://doi.org/10.1002/lary.21997

Esthesioneuroblastoma : Correlating FDG uptake on PET/T with tumor histologic grade. / Harirchian, Sanaz; Kuperan, Arjuna B.; Ghesani, Nasrin; Mirani, Neena M.; Cohen, Erik G.; Baredes, Soly.

In: Laryngoscope, Vol. 121, No. SUPPL. 4, 11.07.2011.

Research output: Contribution to journalArticle

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T1 - Esthesioneuroblastoma

T2 - Correlating FDG uptake on PET/T with tumor histologic grade

AU - Harirchian, Sanaz

AU - Kuperan, Arjuna B.

AU - Ghesani, Nasrin

AU - Mirani, Neena M.

AU - Cohen, Erik G.

AU - Baredes, Soly

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N2 - OBJECTIVES: Esthesioneuroblastoma (ENB) is a rare neoplasm arising from the olfactory epithelium of the upper nasal cavity. It exhibits varied clinical behavior with the potential for locoregional recurrence and metastasis. The utility of PET/CT in the evaluation, staging, and follow-up of patients with ENB has not been well characterized, nor has the relationship between PET/CT findings and histologic grade. This study aims to evaluate the potential clinical utility of PET/CT in predicting the tumor's histologic grade. Study design: Retrospective chart review Methods: Seven patients treated for ENB who also had a PET/CT scan were included in the study. All patients had PET/CT scans 1-6 weeks before surgery, and lesions were assigned a peak SUV (standardized uptake value) that was standardized to the liver uptake. Pathology specimens were categorized into grades I-IV according to Hyams histologic grading criteria. The ratio of the lesion to liver uptake was then plotted against the pathological grade of the surgical specimen. Results: Six out of seven patients had direct correlation between the degree of lesion uptake on PET/CT and Hyams histologic grade. Conclusions: This study correlates histologic grade of ENB with FDG avidity on PET/CT. Recent data in the literature notes that the Hyams staging system may be an important factor in determining prognosis for tumor recurrence and survival. Although a small series, our study suggests that PET/CT may be utilized to predict the tumor's histologic grade. Lesion uptake on PET/CT may be utilized as a predictor of outcome and the need for post-surgical adjunctive treatment.

AB - OBJECTIVES: Esthesioneuroblastoma (ENB) is a rare neoplasm arising from the olfactory epithelium of the upper nasal cavity. It exhibits varied clinical behavior with the potential for locoregional recurrence and metastasis. The utility of PET/CT in the evaluation, staging, and follow-up of patients with ENB has not been well characterized, nor has the relationship between PET/CT findings and histologic grade. This study aims to evaluate the potential clinical utility of PET/CT in predicting the tumor's histologic grade. Study design: Retrospective chart review Methods: Seven patients treated for ENB who also had a PET/CT scan were included in the study. All patients had PET/CT scans 1-6 weeks before surgery, and lesions were assigned a peak SUV (standardized uptake value) that was standardized to the liver uptake. Pathology specimens were categorized into grades I-IV according to Hyams histologic grading criteria. The ratio of the lesion to liver uptake was then plotted against the pathological grade of the surgical specimen. Results: Six out of seven patients had direct correlation between the degree of lesion uptake on PET/CT and Hyams histologic grade. Conclusions: This study correlates histologic grade of ENB with FDG avidity on PET/CT. Recent data in the literature notes that the Hyams staging system may be an important factor in determining prognosis for tumor recurrence and survival. Although a small series, our study suggests that PET/CT may be utilized to predict the tumor's histologic grade. Lesion uptake on PET/CT may be utilized as a predictor of outcome and the need for post-surgical adjunctive treatment.

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