Myxococcus xanthus, a gram‐negative bacterium exhibits a spectacular life cycle and social behavior. Its developmental cycle and multicellular morphogenesis resemble those of eukaryotic slime molds such as Dictyostelium discoideum. On the basis of this resemblance, we explored the existence of eukaryotic‐like protein serine/threonine kinases which are known to play important roles in signal transduction during development of D. discoideum. It was indeed found that M. xanthus contains a large family of protein serine/threonine kinases related to the eukaryotic enzymes. This is the first unambiguous demonstration of eukaryotic‐like protein serine/threonine kinases in the prokaryotes. © 1993 Wiley‐Liss, Inc.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology
- protein kinases