Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish

Grace Buchanan-Kilbey, Joshua Djumpah, Maria V. Papadopoulou, William Bloomer, Longqin Hu, Shane R. Wilkinson, Rachel Ashworth

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.

Original languageEnglish (US)
Pages (from-to)701-705
Number of pages5
JournalActa Tropica
Volume128
Issue number3
DOIs
StatePublished - Dec 1 2013

All Science Journal Classification (ASJC) codes

  • Parasitology
  • veterinary (miscalleneous)
  • Insect Science
  • Infectious Diseases

Keywords

  • Development
  • Protozoa
  • Toxicity
  • Trypanosome
  • Zebrafish

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