Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats

Tracy G. Anthony, Emily T. Mirek, Albert Raouf Bargoud, Lindsey Phillipson-Weiner, Christopher M. DeOliveira, Berish Wetstein, Brittany L. Graf, Peter E. Kuhn, Ilya Raskin

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Phytoecdysteroids such as 20-hydroxyecdysone (20HE) are nutritional supplements marketed as enhancers of lean body mass. In this study the impact of 20HE ingestion on protein kinase B/Akt-mechanistic target of rapamycin complex 1 signaling in the skeletal muscle and liver of male rats was found to be limited. Bioavailability of 20HE, whether consumed alone or with leucine, also remained low at all doses ingested. Additional work is necessary to clarify 20HE mechanism of action in vivo.

Original languageEnglish (US)
Pages (from-to)1324-1328
Number of pages5
JournalApplied Physiology, Nutrition and Metabolism
Volume40
Issue number12
DOIs
StatePublished - Aug 14 2015

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

Keywords

  • 4E-BP1
  • Leucine
  • MTOR
  • PKB/Akt
  • Phytoecdysteroids

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