Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver

Takao Itoi, Hiroyuki Isayama, Atsushi Sofuni, Fumihide Itokawa, Miho Tamura, Yusuke Watanabe, Fuminori Moriyasu, Michel Kahaleh, Nagy Habib, Toshitaka Nagao, Tomohisa Yokoyama, Kazuhiko Kasuya, Hiroshi Kawakami

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Background: The effects of ablation with various settings of powers and times using a newly developed radiofrequency (RF) ablation device, the HabibTM EndoHPB catheter, are not well known. In the present study, we examined the effects of a novel RF ablation catheter using resected fresh pig livers and evaluated the macroand microscopic effects of RF ablation under various conditions. Materials and methods: The RF application was performed step by step at 5, 10, 15, and 20 W power and 60, 90, 120 s, respectively. Macroscopic and microscopic findings of the ablation area were evaluated at each setting. Results The mean lengths of the short axis of the ablation area at 10 W and 60, 90 and 120 s were 8.0 ± 1.0, 8.3 ± 1.2, and 9.7 ± 0.6 mm, respectively. The mean lengths of the long axis at 10 W power and 60, 90 and 120 s were 20.3 ± 0.6, 21.3 ± 1.6, and 28.3 ± 2.1 mm, respectively. Although the lengths of the short and long axes at 5 and 10 W increased gradually with power, there were no obvious differences in either short or long axis lengths between 15 and 20 W. Of all the settings, only at 5 W and 60 and 90 s did the long axis of the ablation show separate areas around the 2 ring electrodes. Conclusions: Although other sequelae including hemorrhage, pancreatitis, acute inflammatory changes, perforation and late fibrosis could not be investigated in our ex-vivo pig model, our study clarified the relationship between ablation powers and times and the effects concerning depth and longitudinal spread of ablation. Although the clinical ablation setting at 7-10 W power and 2 min is suitable, ultimately the ablation power and time should be adjusted according to the size of masses using examples from the present results.

Original languageEnglish (US)
Pages (from-to)543-547
Number of pages5
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Issue number5
StatePublished - Sep 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology


  • Endoscopic retrograde cholangiopancreatography
  • Radiofrequency
  • Stent


Dive into the research topics of 'Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver'. Together they form a unique fingerprint.

Cite this