Evaluation of inflammatory cell activation induced by polymeric materials using a rodent air-pouch model

Kimberly A. Hooper, Thomas L. Nickolas, Natalie D. Macon, Debra L. Laskin, Joachim Kohn

Research output: Contribution to conferencePaperpeer-review

Abstract

A rodent air pouch model was used to evaluate the inflammatory cell activation induced by polymeric implants. This allows the evaluation of the cellular response to the implant, including the identification of the mediators produced by the cells and the activation level of cells infiltrating into the pouch or adhering to the implant. The response of inflammatory cells migrating into pouches containing poly(DTE carbonate), a degradable tyrosine-derived polycarbonate, and poly(L-lactic acid) were evaluated after 2 and 7 days. Results show that the type of material did not affect the number or composition of the cells isolated from the pouch.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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