Evidence against transmission of human t-lymphotropic virus/lymphadenopathy-associated virus (HTLV-III/LAV) in families of children with the acquired immunodeficiency syndrome

Jonathan E. Kaplan, James M. Oleske, Jane P. Getchell, Vaniambabi S. Kalyanaraman, Anthony B. Minnefor, May Zabala-Ablan, Vijay Joshi, Thomas Denny, Cirilo D. Cabradilla, Martha F. Rogers, Mangalasseril G. Sarngadhara, Ann Sliski, Robert C. Gallo, Donald P. Francis

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Six children with the acquired immunodeficiency syndrome (AIDS) and 12 of their household contacts were investigated serologically for evidence of infection with human T-lympho-tropic virus/lymphadenopathy-associated virus (HTLV-III/LAV), the presumed etiologic agent of AIDS. All six children had antibody against HTLV-III/LAV, as measured by enzyme-linked immunosorbent assay, in each specimen tested. Of the two mothers studied both were seropositive; one was diagnosed with and died from AIDS. Four of the remaining 10 household members were seropositive, including three adults in groups at high risk for the development of AIDS and one sibling who was younger than the child with AIDS. Among the seronegative household contacts were four foster mothers or grandmothers of the children with AIDS, three of whom had cared for the children since infancy. Household contacts of children with AIDS may include persons in groups at high risk for AIDS who have been infected with HTLV-III/LAV. However, the negative findings in household contacts without risk factors for AIDS suggest that horizontal transmission of the virus within households by means other than sexual contact must be infrequent.

Original languageEnglish (US)
Pages (from-to)468-471
Number of pages4
JournalPediatric Infectious Disease
Volume4
Issue number5
DOIs
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Fingerprint

Dive into the research topics of 'Evidence against transmission of human t-lymphotropic virus/lymphadenopathy-associated virus (HTLV-III/LAV) in families of children with the acquired immunodeficiency syndrome'. Together they form a unique fingerprint.

Cite this