Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: An association study in a South American population isolate

Barbara Kremeyer, Jenny García, Hanna Kymäläinen, Naomi Wratten, Gabriel Restrepo, Carlos Palacio, Ana Lucía Miranda, Carlos López, Margarita Restrepo, Gabriel Bedoya, Linda M. Brzustowicz, Jorge Ospina-Duque, María Patricia Arbeláez, Andrés Ruiz-Linares

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background/Aims: Recent studies have implicated a region on chromosome 1q21-23, including the NOS1AP gene, in susceptibility to schizophrenia. However, replication studies have been inconsistent, a fact that could partly relate to the marked psychopathological heterogeneity of schizophrenia. The aim of this study is to evaluate association of polymorphisms in the NOS1AP gene region to schizophrenia, in patients from a South American population isolate, and to assess if these variants are associated with specific clinical dimensions of the disorder. Methods: We genotyped 24 densely spaced SNPs in the NOS1AP gene region in a schizophrenia trio sample. The transmission disequilibrium test (TDT) was applied to single marker and haplotype data. Association to clinical dimensions (identified by factor analysis) was evaluated using a quantitative transmission disequilibrium test (QTDT). Results: We found significant association between eight SNPs in the NOS1AP gene region to schizophrenia (minimum p value = 0.004). The QTDT analysis of clinical dimensions revealed an association to a dimension consisting mainly of negative symptoms (minimum p value 0.001). Conclusions: Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the 'negative syndrome' of the disorder.

Original languageEnglish (US)
Pages (from-to)163-173
Number of pages11
JournalHuman Heredity
Volume67
Issue number3
DOIs
StatePublished - Feb 2009

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Keywords

  • Clinical heterogeneity
  • Genetic association
  • NOS1AP
  • Psychiatric genetics
  • Schizophrenia

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