Evidence for a susceptibility locus for schizophrenia on chromosome 6pter–p22

Shengbiao Wang, Cui E. Sun, Cynthia A. Walczak, Janet S. Ziegle, Barbara R. Kipps, Lynn R. Goldin, Scott R. Diehl

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214 Scopus citations


We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P=2.3 × 10−5) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5–8%. The non–parametric affected pedigree member test provided results (P=3 × 10−4) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia orr distal chromosome 6p, and support a model of locus heterogeneity.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalNature genetics
Issue number1
StatePublished - May 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics


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