Evidence for a susceptibility locus for schizophrenia on chromosome 6pter–p22

Shengbiao Wang; Cui E. Sun; Cynthia A. Walczak; Janet S. Ziegle; Barbara R. Kipps; Lynn R. Goldin; Scott R. Diehl

doi:10.1038/ng0595-41

Evidence for a susceptibility locus for schizophrenia on chromosome 6pter–p22

Shengbiao Wang, Cui E. Sun, Cynthia A. Walczak, Janet S. Ziegle, Barbara R. Kipps, Lynn R. Goldin, Scott R. Diehl

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214 Scopus citations

Abstract

We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P=2.3 × 10⁻⁵) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5–8%. The non–parametric affected pedigree member test provided results (P=3 × 10⁻⁴) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia orr distal chromosome 6p, and support a model of locus heterogeneity.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	Nature genetics
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/ng0595-41
State	Published - May 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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title = "Evidence for a susceptibility locus for schizophrenia on chromosome 6pter–p22",

abstract = "We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P=2.3 × 10−5) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5–8%. The non–parametric affected pedigree member test provided results (P=3 × 10−4) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia orr distal chromosome 6p, and support a model of locus heterogeneity.",

author = "Shengbiao Wang and Sun, {Cui E.} and Walczak, {Cynthia A.} and Ziegle, {Janet S.} and Kipps, {Barbara R.} and Goldin, {Lynn R.} and Diehl, {Scott R.}",

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AU - Wang, Shengbiao

AU - Sun, Cui E.

AU - Walczak, Cynthia A.

AU - Ziegle, Janet S.

AU - Kipps, Barbara R.

AU - Goldin, Lynn R.

AU - Diehl, Scott R.

PY - 1995/5

Y1 - 1995/5

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Evidence for a susceptibility locus for schizophrenia on chromosome 6pter–p22

Abstract

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