Evidence for autoregulation of cystathionine -γ-synthase mRNA stability in Arabidopsis

Yukako Chiba, Mari Ishikawa, Fumiko Kijima, R. Huw Tyson, Jungsup Kim, Ayako Yamamoto, Eiji Nambara, Thomas Leustek, Roger M. Wallsgrove, Satoshi Naito

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

Control of messenger RNA (mRNA) stability serves as an important mechanism for regulating gene expression. Analysis of Arabidopsis mutants that overaccumulate soluble methionine (Met) revealed that the gene for cystathionine γ-synthase (CGS), the key enzyme in Met biosynthesis, is regulated at the level of mRNA stability. Transfection experiments with wild- type and mutant forms of the CGS gene suggest that an amino acid sequence encoded by the first exon of CGS acts in cis to destabilize its own mRNA in a process that is activated by Met or one of its metabolites.

Original languageEnglish (US)
Pages (from-to)1371-1374
Number of pages4
JournalScience
Volume286
Issue number5443
DOIs
StatePublished - Nov 12 1999

All Science Journal Classification (ASJC) codes

  • General

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