Evidence for linked expression of latent allotypes of the heavy chain constant and variable regions

M. L. Yarmush, W. J. Mandy, T. J. Kindt

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

C(H) allotypes were determined for rabbit IgG and antibody molecules identified and isolated on the basis of their expression of latent group a (V(H)) allotypic determinants. Serologic and chemical typing of the purified molecules revealed that five out of 10 individual preparations studied expressed d allotypes not present in the rabbit as a nominal allotype. None of the latent V(H)-C(H) combinations represented products of a new or unusual arrangement of V(H) and C(H) structural genes. This result indicates that the molecules with latent allotypes express their V(H) and C(H) allotypes in the same combinations as do their nomal counterparts and do not result from misspairing of separate genes involved in H chain synthesis.

Original languageEnglish (US)
Pages (from-to)2864-2869
Number of pages6
JournalJournal of Immunology
Volume124
Issue number6
StatePublished - Jan 1 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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