Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia

Patricia L. Faris, Barry Komisaruk, Linda R. Watkins, David J. Mayer

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The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.

Original languageEnglish (US)
Pages (from-to)310-312
Number of pages3
Issue number4582
StatePublished - Jan 1 1983


All Science Journal Classification (ASJC) codes

  • General

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