Evidence for the role of spinal cord systems in Parkinson's disease-associated pain

J. I. Sage, H. I. Kortis, W. Sommer

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A patient with Parkinson's disease had severe levodopa-associated leg pain in a beginning-of-dose and peak-dose pattern. Local anesthetic block of the lumbar sympathetic chain or differential epidural block did not alter the pain. Spinal anesthesia abolished the pain. We postulate that levodopa-associated pain in Parkinson's disease either originates in or is mediated by spinal cord dopaminergic systems.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalClinical Neuropharmacology
Volume13
Issue number2
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

Keywords

  • Pain
  • Parkinson's disease
  • Spinal cord

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