Evidence for the role of spinal cord systems in Parkinson's disease-associated pain

J. I. Sage; H. I. Kortis; W. Sommer

doi:10.1097/00002826-199004000-00006

Evidence for the role of spinal cord systems in Parkinson's disease-associated pain

J. I. Sage, H. I. Kortis, W. Sommer

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A patient with Parkinson's disease had severe levodopa-associated leg pain in a beginning-of-dose and peak-dose pattern. Local anesthetic block of the lumbar sympathetic chain or differential epidural block did not alter the pain. Spinal anesthesia abolished the pain. We postulate that levodopa-associated pain in Parkinson's disease either originates in or is mediated by spinal cord dopaminergic systems.

Original language	English (US)
Pages (from-to)	171-174
Number of pages	4
Journal	Clinical Neuropharmacology
Volume	13
Issue number	2
DOIs	https://doi.org/10.1097/00002826-199004000-00006
State	Published - 1990

All Science Journal Classification (ASJC) codes

Pharmacology
Clinical Neurology
Pharmacology (medical)

Keywords

Pain
Parkinson's disease
Spinal cord

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10.1097/00002826-199004000-00006

Cite this

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abstract = "A patient with Parkinson's disease had severe levodopa-associated leg pain in a beginning-of-dose and peak-dose pattern. Local anesthetic block of the lumbar sympathetic chain or differential epidural block did not alter the pain. Spinal anesthesia abolished the pain. We postulate that levodopa-associated pain in Parkinson's disease either originates in or is mediated by spinal cord dopaminergic systems.",

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AB - A patient with Parkinson's disease had severe levodopa-associated leg pain in a beginning-of-dose and peak-dose pattern. Local anesthetic block of the lumbar sympathetic chain or differential epidural block did not alter the pain. Spinal anesthesia abolished the pain. We postulate that levodopa-associated pain in Parkinson's disease either originates in or is mediated by spinal cord dopaminergic systems.

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KW - Parkinson's disease

KW - Spinal cord

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Evidence for the role of spinal cord systems in Parkinson's disease-associated pain

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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