Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling

Barth Grant, Yinhua Zhang, Marie Christine Paupard, Sharron X. Lin, David H. Hall, David Hirsh

Research output: Contribution to journalArticlepeer-review

210 Scopus citations

Abstract

In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.

Original languageEnglish (US)
Pages (from-to)573-579
Number of pages7
JournalNature Cell Biology
Volume3
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology

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