Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome

Toru Nakamura, Stephan Schwander, Robert Donnelly, Dane B. Cook, Felix Ortega, Fumiharu Togo, Yoshiharu Yamamoto, Neil S. Cherniack, Marc Klapholz, David Rapoport, Benjamin H. Natelson

Research output: Contribution to journalArticle

13 Scopus citations


A major hypothesis regarding the cause of chronic fatigue syndrome (CFS) is immune dysregulation, thought to be reflected in upregulated proinflammatory cytokines leading to the symptoms that are characteristic of this illness. Because the symptoms worsen with physical exertion or sleep loss, we hypothesized that we could use these stressors to magnify the underlying potential pathogenic abnormalities in the cytokine systems of people with CFS. We conducted repeat blood sampling for cytokine levels from healthy subjects and CFS patients during both postexercise and total sleep deprivation nights and assayed for protein levels in the blood samples, mRNA activity in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found that these environmental manipulations did not produce clinically significant upregulation of proinflammatory cytokines. These data do not support an important role of immune dysregulation in the genesis of stress-induced worsening of CFS.

Original languageEnglish (US)
Pages (from-to)1736-1742
Number of pages7
JournalClinical and Vaccine Immunology
Issue number11
StatePublished - Nov 1 2013


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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