Experimental investigation and modelling of tensile strength of pharmaceutical tablets based on shear force applied by feed frame paddles

Ryoichi Furukawa, Ravendra Singh, Marianthi Ierapetritou

Research output: Contribution to journalArticlepeer-review

Abstract

The feed frame is an essential device used in a rotary tablet press and it improves the performance of the powder filling process into dies. However, the feed frame affects critical quality attributes such as a tensile strength and a dissolution negatively due to a shear applied to powders from feed frame paddles, leading to over-lubrication. This effects may be significant for shear sensitive materials. The work focuses on the effect of tablet press parameters (die disk speed and feed frame speed) and mixture composition (amount of magnesium stearate) on the tensile strength and the prediction of the tensile strength by considering the extent of shear. It is found that within the investigated range of tablet press parameters and the amount of magnesium stearate, the feed frame speed and the amount of magnesium stearate have an impact on the tensile strength. Furthermore, a lubrication model based on the extent of shear is presented to predict the decreasing trend of the tensile strength of tablets during tableting process and the results demonstrate that the prediction of tensile strength is in good agreement with experimental measurements.

Original languageEnglish (US)
Article number120908
JournalInternational Journal of Pharmaceutics
Volume606
DOIs
StatePublished - Sep 5 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Lubrication
  • Residence time distribution (RTD)
  • Shear force
  • Tableting process
  • Tensile strength

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