Experimental modulation and computational model of nano-hydrophobicity

Shuhuan Li; Shumei Zhai; Yin Liu; Hongyu Zhou; Jinmei Wu; Qing Jiao; Bin Zhang; Hao Zhu; Bing Yan

doi:10.1016/j.biomaterials.2015.02.043

Experimental modulation and computational model of nano-hydrophobicity

Shuhuan Li, Shumei Zhai, Yin Liu, Hongyu Zhou, Jinmei Wu, Qing Jiao, Bin Zhang, Hao Zhu, Bing Yan

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We demonstrate that nano-hydrophobicity, which governs the biological aggressiveness of nanoparticles, is determined by the outermost regions of surface ligands. We have also successfully modulated nano-hydrophobicity using systematic surface ligand modifications and built the first computational model of nano-hydrophobicity.

Original language	English (US)
Pages (from-to)	312-317
Number of pages	6
Journal	Biomaterials
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/j.biomaterials.2015.02.043
State	Published - 2015

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

Keywords

Cytotoxicity
Gold
Hydrophilicity/hydrophobicity
Macrophages
Nanoparticle
Transmission electron microscopy (TEM)

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10.1016/j.biomaterials.2015.02.043

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title = "Experimental modulation and computational model of nano-hydrophobicity",

abstract = "We demonstrate that nano-hydrophobicity, which governs the biological aggressiveness of nanoparticles, is determined by the outermost regions of surface ligands. We have also successfully modulated nano-hydrophobicity using systematic surface ligand modifications and built the first computational model of nano-hydrophobicity.",

keywords = "Cytotoxicity, Gold, Hydrophilicity/hydrophobicity, Macrophages, Nanoparticle, Transmission electron microscopy (TEM)",

author = "Shuhuan Li and Shumei Zhai and Yin Liu and Hongyu Zhou and Jinmei Wu and Qing Jiao and Bin Zhang and Hao Zhu and Bing Yan",

note = "Funding Information: We thank Yan Xin, Fei Li and Alexander Sedykh for technical assistance. This work was supported by National Natural Science Foundation of China ( 21137002 ) and the Strategic Priority Research Program of the Chinese Academy of Sciences ( XDB14030401 ). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

doi = "10.1016/j.biomaterials.2015.02.043",

language = "English (US)",

volume = "52",

pages = "312--317",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - Experimental modulation and computational model of nano-hydrophobicity

AU - Li, Shuhuan

AU - Zhai, Shumei

AU - Liu, Yin

AU - Zhou, Hongyu

AU - Wu, Jinmei

AU - Jiao, Qing

AU - Zhang, Bin

AU - Zhu, Hao

AU - Yan, Bing

N1 - Funding Information: We thank Yan Xin, Fei Li and Alexander Sedykh for technical assistance. This work was supported by National Natural Science Foundation of China ( 21137002 ) and the Strategic Priority Research Program of the Chinese Academy of Sciences ( XDB14030401 ). Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015

Y1 - 2015

N2 - We demonstrate that nano-hydrophobicity, which governs the biological aggressiveness of nanoparticles, is determined by the outermost regions of surface ligands. We have also successfully modulated nano-hydrophobicity using systematic surface ligand modifications and built the first computational model of nano-hydrophobicity.

AB - We demonstrate that nano-hydrophobicity, which governs the biological aggressiveness of nanoparticles, is determined by the outermost regions of surface ligands. We have also successfully modulated nano-hydrophobicity using systematic surface ligand modifications and built the first computational model of nano-hydrophobicity.

KW - Cytotoxicity

KW - Gold

KW - Hydrophilicity/hydrophobicity

KW - Macrophages

KW - Nanoparticle

KW - Transmission electron microscopy (TEM)

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U2 - 10.1016/j.biomaterials.2015.02.043

DO - 10.1016/j.biomaterials.2015.02.043

M3 - Article

C2 - 25818437

AN - SCOPUS:84932643892

SN - 0142-9612

VL - 52

SP - 312

EP - 317

JO - Biomaterials

JF - Biomaterials

IS - 1

ER -

Experimental modulation and computational model of nano-hydrophobicity

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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