Experimentally-induced ventricular arrhythmias

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Abstract

Hypoxia and reoxygenation, ischemia and reperfusion, catecholamine infusion, ouabain, sodium pento-barbital and caffeine, can all be used experimentally to induce ventricular arrhythmias. According to the Lambeth Convention guidelines our experimentally-induced ventricular arrhythmias include but are not limited to: ventricular premature beats (VPB), ventricular salvos (VS), ventricular bigeminy (VB), nonsustained ventricular tachycardia (VTn), sustained ventricular tachycardia (VTs) and ventricular fibrillation (VF, or if the heart is not defibrillated, sudden cardiac death). We have studied these arrhythmias in the absence and presence of adenosine deaminase, methyl xanthines, and more recently, acetaminophen. Our laboratory was the first to discover the anti-arrhythmic properties of acetaminophen an analgesic used in Western medicine for more than 100 years before our publication. We have also identified other cardioprotective properties of acetaminophen, and have begun to work out some of the cellular/molecular mechanisms. For example, we know that acetaminophen protects hypoxic/ischemic cardiac mitochondria, in part, by sustaining function of the mitochondrial permeability transition pore (MPTP, a protein involved in regulating mitochondrial pH). Acetaminophen also attenuates the actions of matrix metalloproteinases that can be harmful to myocardial contractile proteins. Of course, like all science, more work is needed to expand on these and related topics.

Original languageEnglish (US)
Article numberIJPPP0064366
Pages (from-to)202-210
Number of pages9
JournalInternational Journal of Physiology, Pathophysiology and Pharmacology
Volume9
Issue number6
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Physiology
  • Physiology (medical)

Keywords

  • Acetaminophen
  • Arrhythmias
  • Hypoxia

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