Explorations of antimitotic agents in the treatment of a congenital disease, Ichthyosis Linearis Circumflexa

Edmund Klein, Gary M. Hahn, James A. Solomon, Untae Kim, Robert A. Schwartz, Robert W. Case, Hannah Herman, Halina Milgrom, Ole A. Holtermann

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Successful therapy of a genetic disorder, Ichthyosis Linearis Circumflexa, was achieved using low dose systemic cyclophosphamide. Prior to such therapy, 80 to 90% of the body surface was affected; the use of antimitotic agents reduced the extent of the lesions to less than 15% of the body surface. As a result, the clinical status was changed from severely disabling to being compatible with a normal way of life. It is believed that this phenomenon is related to selective effects of cyclophosphamide, such as those on lymphocyte subpopulations. To our knowledge, successful chemotherapy for diseases of genetic or congenital origin has not been previously reported.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalJournal of Surgical Oncology
Volume11
Issue number2
DOIs
StatePublished - 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Keywords

  • Ichthyosis Linearis Circumflexa
  • antimitotic agents
  • cyclophosphamide
  • genetic diseases

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