TY - JOUR
T1 - Exploring protein symmetry at the RCSB Protein Data Bank
AU - Duarte, Jose M.
AU - Dutta, Shuchismita
AU - Goodsell, David S.
AU - Burley, Stephen K.
N1 - Funding Information:
RCSB PDB is jointly funded by the National Science Foundation (DBI-1832184, PI: S.K.B.), the US Department of Energy (DE-SC0019749, PI: S.K.B.), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198 (PI: S.K.B.).
Publisher Copyright:
© 2022 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology and distributed under the Creative Commons Attribution License 4.0 (CC BY).
PY - 2022/9
Y1 - 2022/9
N2 - The symmetry of biological molecules has fascinated structural biologists ever since the structure of hemoglobin was determined. The Protein Data Bank (PDB) archive is the central global archive of three-dimensional (3D), atomic-level structures of biomolecules, providing open access to the results of structural biology research with no limitations on usage. Roughly 40% of the structures in the archive exhibit some type of symmetry, including formal global symmetry, local symmetry, or pseudosymmetry. The Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (founding member of the Worldwide Protein Data Bank partnership that jointly manages, curates, and disseminates the archive) provides a variety of tools to assist users interested in exploring the symmetry of biological macromolecules. These tools include multiple modalities for searching and browsing the archive, turnkey methods for biomolecular visualization, documentation, and outreach materials for exploring functional biomolecular symmetry.
AB - The symmetry of biological molecules has fascinated structural biologists ever since the structure of hemoglobin was determined. The Protein Data Bank (PDB) archive is the central global archive of three-dimensional (3D), atomic-level structures of biomolecules, providing open access to the results of structural biology research with no limitations on usage. Roughly 40% of the structures in the archive exhibit some type of symmetry, including formal global symmetry, local symmetry, or pseudosymmetry. The Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (founding member of the Worldwide Protein Data Bank partnership that jointly manages, curates, and disseminates the archive) provides a variety of tools to assist users interested in exploring the symmetry of biological macromolecules. These tools include multiple modalities for searching and browsing the archive, turnkey methods for biomolecular visualization, documentation, and outreach materials for exploring functional biomolecular symmetry.
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U2 - 10.1042/ETLS20210267
DO - 10.1042/ETLS20210267
M3 - Review article
C2 - 35801924
AN - SCOPUS:85138125510
SN - 2397-8554
VL - 6
SP - 231
EP - 243
JO - Emerging topics in life sciences
JF - Emerging topics in life sciences
IS - 3
ER -