Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates

Keyphrases

• Active Sites 50%
• Amides 50%
• Bisphosphonates 50%
• Cell-free Assay 50%
• DNA Complex 50%
• HIV-1 Reverse Transcriptase 100%
• HIV-1 RT 100%
• Inhibitory Activity 50%
• Kinetic Behavior 50%
• L-enantiomer 100%
• Malonate 50%
• Malonate Derivatives 50%
• Metal Chelation 50%
• Novel Mode of Action 50%
• Nucleoside Monophosphates 100%
• Order of Magnitude 50%
• Phosphonoacetic Acid 50%
• Phosphorylation 50%
• Polymerase 50%
• Reverse Transcriptase Inhibition 100%

Biochemistry, Genetics and Molecular Biology

• Active Site 33%
• Chelation 33%
• Crystal Structure 33%
• Enantiomer 66%
• Human Immunodeficiency Virus 100%
• Nucleoside 100%
• Polymerase 33%
• Reverse Transcriptase 100%