Expression and function of a novel isoform of Sox5 in malignant B cells

Shanique K.E. Edwards; Anand Desai; Yan Liu; Carissa R. Moore; Ping Xie

doi:10.1016/j.leukres.2013.12.016

Expression and function of a novel isoform of Sox5 in malignant B cells

Shanique K.E. Edwards, Anand Desai, Yan Liu, Carissa R. Moore, Ping Xie

School of Arts and Sciences, Cell Biology & Neuroscience

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3^-/- B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3^-/- B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.

Original language	English (US)
Pages (from-to)	393-401
Number of pages	9
Journal	Leukemia Research
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.leukres.2013.12.016
State	Published - Mar 2014

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

Keywords

B lymphoma
Multiple myeloma
P27
Sox5
TRAF3
β-Catenin

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10.1016/j.leukres.2013.12.016

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title = "Expression and function of a novel isoform of Sox5 in malignant B cells",

abstract = "Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3-/- B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3-/- B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.",

keywords = "B lymphoma, Multiple myeloma, P27, Sox5, TRAF3, β-Catenin",

author = "Edwards, {Shanique K.E.} and Anand Desai and Yan Liu and Moore, {Carissa R.} and Ping Xie",

note = "Funding Information: This study was supported by the National Institutes of Health grant CA158402 (P. Xie), a seed grant from the New Jersey Commission on Cancer Research (10-1066-CCR-EO, P. Xie), and the Arthur Herrmann Endowed Cancer Research Fund (P. Xie); supported in part by an Aresty Undergraduate Research Grant (A. Desai). The FACS analyses described in this paper were supported by the Flow Cytometry Core Facility of The Cancer Institute of New Jersey (P30CA072720). ",

year = "2014",

month = mar,

doi = "10.1016/j.leukres.2013.12.016",

language = "English (US)",

volume = "38",

pages = "393--401",

journal = "Leukemia Research",

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publisher = "Elsevier Limited",

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T1 - Expression and function of a novel isoform of Sox5 in malignant B cells

AU - Edwards, Shanique K.E.

AU - Desai, Anand

AU - Liu, Yan

AU - Moore, Carissa R.

AU - Xie, Ping

N1 - Funding Information: This study was supported by the National Institutes of Health grant CA158402 (P. Xie), a seed grant from the New Jersey Commission on Cancer Research (10-1066-CCR-EO, P. Xie), and the Arthur Herrmann Endowed Cancer Research Fund (P. Xie); supported in part by an Aresty Undergraduate Research Grant (A. Desai). The FACS analyses described in this paper were supported by the Flow Cytometry Core Facility of The Cancer Institute of New Jersey (P30CA072720).

PY - 2014/3

Y1 - 2014/3

N2 - Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3-/- B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3-/- B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.

AB - Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3-/- B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3-/- B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.

KW - B lymphoma

KW - Multiple myeloma

KW - P27

KW - Sox5

KW - TRAF3

KW - β-Catenin

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U2 - 10.1016/j.leukres.2013.12.016

DO - 10.1016/j.leukres.2013.12.016

M3 - Article

C2 - 24418753

AN - SCOPUS:84894263593

VL - 38

SP - 393

EP - 401

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 3

ER -

Expression and function of a novel isoform of Sox5 in malignant B cells

Abstract

All Science Journal Classification (ASJC) codes

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