Expression and function of a novel isoform of Sox5 in malignant B cells

Shanique K.E. Edwards, Anand Desai, Yan Liu, Carissa R. Moore, Ping Xie

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3-/- B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3-/- B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.

Original languageEnglish (US)
Pages (from-to)393-401
Number of pages9
JournalLeukemia Research
Volume38
Issue number3
DOIs
StatePublished - Mar 2014

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Keywords

  • B lymphoma
  • Multiple myeloma
  • P27
  • Sox5
  • TRAF3
  • β-Catenin

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