Expression of c-fos protein in lumbosacral spinal cord in response to vaginocervical stimulation in rats

Sandra Chinapen; Jennifer M. Swann; Judith L. Steinman; Barry R. Komisaruk

doi:10.1016/0304-3940(92)90211-O

Expression of c-fos protein in lumbosacral spinal cord in response to vaginocervical stimulation in rats

Sandra Chinapen, Jennifer M. Swann, Judith L. Steinman, Barry R. Komisaruk

Research output: Contribution to journal › Article › peer-review

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Abstract

The pattern of vaginocervical stimulation-evoked expression of the proto-oncogene c-fos in lumbar 5-sacral 1 segments of the spinal cord of ovariectomized adult rats was mapped using immunocytochemistry. A calibrated force of mechanostimulation was applied to the vaginal cervix of experimental animals and to the perineum of control animals while they were gently restrained. The number of cells expressing c-fos was significant greater in the experimental than the control animals in laminae I, IV, V-VI and X. The implications of the present findings for elucidating the spinal pathways mediating the various behavioral, neuroendocrine and autonomic effects of vaginocervical stimulation (VS) are discussed.

Original language	English (US)
Pages (from-to)	93-96
Number of pages	4
Journal	Neuroscience Letters
Volume	145
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(92)90211-O
State	Published - Sep 28 1992

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

C-fos
Sacral parasympathetic nucleus
Spinal cord
Vaginocervical stimulation
Visceral afferent pathways

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10.1016/0304-3940(92)90211-O

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title = "Expression of c-fos protein in lumbosacral spinal cord in response to vaginocervical stimulation in rats",

abstract = "The pattern of vaginocervical stimulation-evoked expression of the proto-oncogene c-fos in lumbar 5-sacral 1 segments of the spinal cord of ovariectomized adult rats was mapped using immunocytochemistry. A calibrated force of mechanostimulation was applied to the vaginal cervix of experimental animals and to the perineum of control animals while they were gently restrained. The number of cells expressing c-fos was significant greater in the experimental than the control animals in laminae I, IV, V-VI and X. The implications of the present findings for elucidating the spinal pathways mediating the various behavioral, neuroendocrine and autonomic effects of vaginocervical stimulation (VS) are discussed.",

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AU - Chinapen, Sandra

AU - Swann, Jennifer M.

AU - Steinman, Judith L.

AU - Komisaruk, Barry R.

PY - 1992/9/28

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N2 - The pattern of vaginocervical stimulation-evoked expression of the proto-oncogene c-fos in lumbar 5-sacral 1 segments of the spinal cord of ovariectomized adult rats was mapped using immunocytochemistry. A calibrated force of mechanostimulation was applied to the vaginal cervix of experimental animals and to the perineum of control animals while they were gently restrained. The number of cells expressing c-fos was significant greater in the experimental than the control animals in laminae I, IV, V-VI and X. The implications of the present findings for elucidating the spinal pathways mediating the various behavioral, neuroendocrine and autonomic effects of vaginocervical stimulation (VS) are discussed.

AB - The pattern of vaginocervical stimulation-evoked expression of the proto-oncogene c-fos in lumbar 5-sacral 1 segments of the spinal cord of ovariectomized adult rats was mapped using immunocytochemistry. A calibrated force of mechanostimulation was applied to the vaginal cervix of experimental animals and to the perineum of control animals while they were gently restrained. The number of cells expressing c-fos was significant greater in the experimental than the control animals in laminae I, IV, V-VI and X. The implications of the present findings for elucidating the spinal pathways mediating the various behavioral, neuroendocrine and autonomic effects of vaginocervical stimulation (VS) are discussed.

KW - C-fos

KW - Sacral parasympathetic nucleus

KW - Spinal cord

KW - Vaginocervical stimulation

KW - Visceral afferent pathways

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Expression of c-fos protein in lumbosacral spinal cord in response to vaginocervical stimulation in rats

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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