Expression of c-fos protein in lumbosacral spinal cord in response to vaginocervical stimulation in rats

Sandra Chinapen, Jennifer M. Swann, Judith L. Steinman, Barry Komisaruk

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40 Scopus citations

Abstract

The pattern of vaginocervical stimulation-evoked expression of the proto-oncogene c-fos in lumbar 5-sacral 1 segments of the spinal cord of ovariectomized adult rats was mapped using immunocytochemistry. A calibrated force of mechanostimulation was applied to the vaginal cervix of experimental animals and to the perineum of control animals while they were gently restrained. The number of cells expressing c-fos was significant greater in the experimental than the control animals in laminae I, IV, V-VI and X. The implications of the present findings for elucidating the spinal pathways mediating the various behavioral, neuroendocrine and autonomic effects of vaginocervical stimulation (VS) are discussed.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalNeuroscience Letters
Volume145
Issue number1
DOIs
StatePublished - Sep 28 1992

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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