Expression of proto-oncogenes and muscle specific genes during cardiac hypertrophy and development in rats and humans

G. Jegadeesh Babu, N. Selvamurugan, C. Kartha, C. Rajamanickam

Research output: Contribution to journalArticle

Abstract

A regulatory interdependence of expression of proto-oncogenes and muscle specific genes observed in smooth muscle was examined in cardiac muscle during normal development and hypertrophy both in rats and humans. During normal development in rats, myosin light chain 2 expression is very low at prenatal stages, while c-fos expression starts from the early stages of embryonic development. In aorta constricted rats c-fos induction occurs within 30 min whereas myosin light chain 2 expression is sufficiently high only after 3 or 4 days of post operative period. In the case of humans, the expression of myosin light chain 2 as well as c-fos occurs at high levels during embryonic development. Similar results were obtained with tissue samples obtained from patients with cardiac abnormalities. Induction of the c-fos gene in cultured myocytes by 12-O-tetradeeanoylphorbol 13-acetate has no influence on the expression of myosin light chain 2. These studies were extended with studies on c-myc and Β-myosin heavy chain gene expression which revealed a similar pattern of expression as that of c-fos and myosin light chain 2. These results have indicated that the expression of proto-oncogenes in cardiac muscle may be independently regulated from the expression of muscle specific genes.

Original languageEnglish (US)
Pages (from-to)155-169
Number of pages15
JournalJournal of Biosciences
Volume19
Issue number2
DOIs
StatePublished - Jun 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Keywords

  • Atrial septal defect
  • TPA
  • c-myc
  • cardiac hypertrophy
  • myosin light chain 2
  • mysoin heavy chain (MHC)
  • tetralogy of Fallot

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