Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage

Serge Nataf; Steven W. Levison; Scott R. Barnum

doi:10.1016/S0006-8993(01)02003-0

Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage

Serge Nataf, Steven W. Levison, Scott R. Barnum

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Expression of the C5a receptor in the central nervous system has been demonstrated on microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in vitro by rat and murine O2-A progenitor cells and oligodendrocytes. We also observed that in vitro differentiation of O2-A progenitors into mature oligodendrocytes is accompanied by down-regulation of C5aR mRNA expression. These results suggest that the C5aR may be a marker for oligodendroglial differentiation and play a role in oligodendrocyte function.

Original language	English (US)
Pages (from-to)	321-326
Number of pages	6
Journal	Brain research
Volume	894
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)02003-0
State	Published - Mar 16 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Complement
G-protein-coupled receptor
Myelin
O2-A progenitors

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10.1016/S0006-8993(01)02003-0

Cite this

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title = "Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage",

abstract = "Expression of the C5a receptor in the central nervous system has been demonstrated on microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in vitro by rat and murine O2-A progenitor cells and oligodendrocytes. We also observed that in vitro differentiation of O2-A progenitors into mature oligodendrocytes is accompanied by down-regulation of C5aR mRNA expression. These results suggest that the C5aR may be a marker for oligodendroglial differentiation and play a role in oligodendrocyte function.",

keywords = "Complement, G-protein-coupled receptor, Myelin, O2-A progenitors",

author = "Serge Nataf and Levison, {Steven W.} and Barnum, {Scott R.}",

note = "Funding Information: This study was supported by NIH grant NS29719 (to S.R.B.), advanced post-doctoral fellowship (FA 1306) from the National Multiple Sclerosis Society (to S.N.) and RG-3837 awarded by the NMSS to SWL.",

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doi = "10.1016/S0006-8993(01)02003-0",

language = "English (US)",

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TY - JOUR

T1 - Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage

AU - Nataf, Serge

AU - Levison, Steven W.

AU - Barnum, Scott R.

N1 - Funding Information: This study was supported by NIH grant NS29719 (to S.R.B.), advanced post-doctoral fellowship (FA 1306) from the National Multiple Sclerosis Society (to S.N.) and RG-3837 awarded by the NMSS to SWL.

PY - 2001/3/16

Y1 - 2001/3/16

N2 - Expression of the C5a receptor in the central nervous system has been demonstrated on microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in vitro by rat and murine O2-A progenitor cells and oligodendrocytes. We also observed that in vitro differentiation of O2-A progenitors into mature oligodendrocytes is accompanied by down-regulation of C5aR mRNA expression. These results suggest that the C5aR may be a marker for oligodendroglial differentiation and play a role in oligodendrocyte function.

AB - Expression of the C5a receptor in the central nervous system has been demonstrated on microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in vitro by rat and murine O2-A progenitor cells and oligodendrocytes. We also observed that in vitro differentiation of O2-A progenitors into mature oligodendrocytes is accompanied by down-regulation of C5aR mRNA expression. These results suggest that the C5aR may be a marker for oligodendroglial differentiation and play a role in oligodendrocyte function.

KW - Complement

KW - G-protein-coupled receptor

KW - Myelin

KW - O2-A progenitors

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JO - Brain research

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Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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