Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus

Yanan Zhao; Padmaja Paderu; Steven Park; Aleksandra Dukhan; Meredith Senter; David S. Perlin

doi:10.1128/AAC.06163-11

Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus

Yanan Zhao, Padmaja Paderu, Steven Park, Aleksandra Dukhan, Meredith Senter, David S. Perlin

NJMS-PHRI CENTER

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.

Original language	English (US)
Pages (from-to)	2770-2772
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	56
Issue number	5
DOIs	https://doi.org/10.1128/AAC.06163-11
State	Published - May 2012

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.06163-11

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abstract = "Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.",

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Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus. / Zhao, Yanan; Paderu, Padmaja; Park, Steven; Dukhan, Aleksandra; Senter, Meredith; Perlin, David S.

In: Antimicrobial agents and chemotherapy, Vol. 56, No. 5, 05.2012, p. 2770-2772.

Research output: Contribution to journal › Article › peer-review

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AU - Perlin, David S.

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Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus

Abstract

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