Abstract
Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.
Original language | English (US) |
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Pages (from-to) | 2770-2772 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 56 |
Issue number | 5 |
DOIs | |
State | Published - May 2012 |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases