Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus

Yanan Zhao, Padmaja Paderu, Steven Park, Aleksandra Dukhan, Meredith Senter, David S. Perlin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.

Original languageEnglish (US)
Pages (from-to)2770-2772
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume56
Issue number5
DOIs
StatePublished - May 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus'. Together they form a unique fingerprint.

Cite this