Extracellular matrix molecules: Synaptic plasticity and learning

A. Dityatev, A. Irintchev, F. Morellini, M. Schachner

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Extracellular matrix molecules (ECMs), derived from both neurons and glial cells, are secreted and accumulate in the extracellular space. They not only regulate different aspects of synapse formation and maturation during development of nervous system but also influence hippocampal synaptic plasticity and learning and memory in the adult. The emerging mechanisms comprise interactions of ECMs with their cognate cell surface receptors, including integrins, and lipoprotein and GABA B receptors. These mechanisms significantly contribute to induction of long-term potentiation in excitatory synapses either via regulation of Ca 2+ entry through NMDA receptors or L-type Ca 2+ channels or via control of GABAergic inhibition.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages8
ISBN (Print)9780080450469
StatePublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


  • Extracellular matrix
  • Glycoproteins
  • HNK-1 carbohydrate
  • Integrins
  • Laminin
  • Learning
  • Long-term depression
  • Long-term potentiation
  • Memory
  • Proteoglycan
  • Reelin
  • Synaptic plasticity
  • Tenascin-C
  • Tenascin-R


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